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We exist to help patients and their families live better lives.

Our Values

We love science and our values bind us together to create an environment that is as unique as our research. We are building a company culture where everyone can belong, contribute and grow. Join us.

We connect to and are inspired by our mission to drive innovation and unlock our full potential. We strive for this every day and in every role, so that each Entradan can grow and fully contribute to our community.

Entrada takes care of you so you can focus on our science and mission; our perks and benefits are designed to meet your needs regardless of what season of life you are in. We celebrate the big and the small and rally around our collective ability to make a difference in the lives of patients and their families.

  • Humanity

    We genuinely care about patients and about one another.

  • Tenacity

    We're relentless and persistent in the pursuit of developing therapies for patients.

  • Creativity

    We're creative problem solvers.

  • Collaboration

    We're more than the sum of our parts.

  • Curiosity

    We've got a growth mindset.

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Listen as Dipal Doshi, our CEO, shares more about our mission, the culture we’re building and how we’re working together to develop new therapies to treat devastating diseases.

Meet Our Entradans

  • BK Choi, PhD, Senior Principal Scientist, Product Development
    BK Choi, PhD
    Senior Director, Biologics & Product Development
  • Murali Mallem, VP and Head of CMC
    Murali Mallem
    VP and Head of CMC
  • Kimberli Kamer, PhD, Senior Scientist, Pharmacology
    Kimberli Kamer, PhD
    Senior Scientist II, Pharmacology
  • Nanjun Liu, Associate Director, Bioanalytical Lead
    Nanjun Liu
    Director, Bioanalytical Lead
  • Nick Long, PhD, Senior Scientist, Antibody and Protein Engineering
    Nick Long, PhD
    Senior Scientist II, Antibody and Protein Engineering
  • Sara Blake, Research Associate II, Neuromuscular and Cardiac Biology
    Sara Blake
    Senior Research Associate, Neuromuscular and Cardiac Biology
  • Nelsa Estrella, PhD, Associate Director, Neuromuscular Therapeutics
    Nelsa Estrella, PhD
    Director, Neuromuscular Therapeutics
  • Leo Qian, PhD, Co-founder & VP, Discovery Research
    Leo Qian, PhD
    Co-founder & VP, Discovery Research
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What Sets Us Apart:

Since our inception, we have worked to build a high-performing, inclusive and diverse team, which is a core element of our culture. Entradans are committed to making a difference in the lives of patients, their families and care partners. We believe that by embracing differences, we have a unique advantage in challenging the status quo to apply innovative thinking to long-existing medical challenges. 

  • 56% Identify as women
  • 52% Asian, Hispanic, Latino, Black, or African American
  • 62% Of our Senior Leadership Team and Board is made up of women and minorities

Self-reported, as of March 2024.

Our Comprehensive Benefits:

  • Wellness

    We offer a $500 wellness benefit to support you and your individual priorities.

  • Fuel

    Subsidized lunches, snacks, cold brew, drinks and treats.

  • Commuter Benefits

    We offer $300 to cover your commute, however you do it.

  • Connections

    Organized coffee dates, company-wide activities and gatherings.

  • Development & Learning

    We offer individual and broad approaches to growth.

  • Mobile Stipend

    We help you stay connected by offsetting your data plan.

  • Swag

    We always offer opportunities to show your love for Entrada.

  • Parental Leave

    We give you time to connect and bond with your new child.

  • Milestones

    Personal or professional, we celebrate the big and small stuff.

Excited by what you see? Check out our Current Openings and Benefits and apply to join the Entrada team!

Learn About Our Benefits

We wish we didn’t have to say this, but please beware of fraud

Some individuals may receive fraudulent interview requests or employment offers from a person or organization posing as Entrada Therapeutics. They will often request personal information and/or payment to complete the interview or hiring process. Recent scams have utilized slightly modified versions of this domain or have used public domains (gmail, yahoo, outlook, etc) for their fraudulent communications. If you fear that you have been a victim of an employment application scam, please contact the Internet Crimes Complaint Center at www.IC3.gov. 

Such as passport details or social security numbers, financial information or payment from job seekers. During our formal recruitment process, you will interview with a member of the recruitment team and any email communications received from an employee will end in “entradatx.com”. In addition, all legitimate openings and positions will be posted to our website at https://www.entradatx.com/careers.

2023 Best Places to Work Presented by Biospace - see our open positions Boston Globe Best Places to Work in Massachusetts 2024 - see our open positions Winner MassEcon Impact Award - see our open positions

Current Openings

Check out our current openings below.

There's more to explore

Who We Are

Meet our leadership team

Platform

Learn about our EEV™ Platform

Pipeline

Discover our pipeline of programs

Principal Scientist, Clinical Biomarkers

The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.

Our Endosomal Escape Vehicle (EEV™)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immunological diseases, among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

You are excited about the opportunity to support and lead clinical biomarker development at Entrada. You enjoy a fast-paced environment and juggling competing priorities. You bring an in-depth knowledge of assay development, qualification, and validation and a broad understanding of regulatory expectations supporting assay performance across various stages of clinical development. You follow up and follow through, efficiently connecting problems with solutions. You work successfully in a team environment, with strong people skills to effectively build working relationships inside and outside of the company.

The Opportunity

The Principal Scientist, Clinical Biomarkers, will lead scientific efforts in developing and executing biomarker assays to support clinical trials. This position will lead both at external CROs and specialty labs and perform technical and strategic assessments of new and innovative biomarker platforms to support Entrada’s drug development pipeline. Additionally, this role will support the internal biomarker team and provide mentorship and training to team members at various levels of skill and competencies. The candidate must possess effective project management skills and communicate progress and risks toward the timely delivery of biomarker assays to support clinical programs.

Responsibilities

  • Lead internal clinical biomarker initiatives in the development, transfer, and execution of stage-appropriate biomarker assays for clinical development.
  • Effectively identify the appropriate biomarker tests and technology solutions to support ongoing and planned clinical trials.
  • Demonstrate an established depth and/or breadth of expertise in biomarker assays and provide strong technical guidance; managing the assay development/transfer and oversee fit-for-purpose assay validation at selected vendors.
  • Provide input on biomarker-related sections of clinical study protocols and health authority submission documents.
  • Operationalize biomarker tests and ensure results are delivered and archived per clinical development needs.
  • Collaborate with Program Team Leaders, Regulatory, and Medical Directors in the review of clinical protocols, investigator training documents, lab manuals, clinical sample analysis, and regulatory submission activities for clinical development.
  • Partner with Discovery and Product Development teams in the evaluation and development of clinical biomarker assays and vendor selection for early projects.
  • Manage, identify, and communicate risks to stakeholders in a clear and timely fashion.
  • Actively engage with industry professionals via attendance and delivery of presentations in conferences, workshops, focus groups, and literature/publications to guide best practices for biomarker development and clinical implementation.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

  • Humanity - We genuinely care about patients and about one another.
  • Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
  • Creativity - We are creative problem solvers.
  • Collaboration - We are more than the sum of our parts.
  • Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

  • Ph.D. with 5+ years of relevant experience or masters in a scientific discipline with 8+ years relevant experience.
  • Extensive experience in defining and executing “fit-for-purpose” clinical biomarker assays that address key scientific and clinical questions.
  • Extensive understanding and experience in ligand binding assay technologies (e.g. ELISA, MSD) and molecular assays (e.g. qPCR, ddPCR, western blot) and related software for data analysis.
  • Experience in outsourcing and managing activities at CROs (e.g. managing timelines and technical troubleshooting) and overseeing development and validation of clinical biomarker assays in a GLP and GCP(GXP) environment.
  • Deep experience and broad technical knowledge related to analyzing complex data.
  • Strong verbal and written communication and presentation skills.
  • Strong interpersonal skills and knowledge of intercultural differences; adept at working across multiple functions to drive decision making.
  • Experience working in a fast-paced, cross-functional environment with multiple competing priorities.
  • This role follows a hybrid working model, with in office attendance 2-3 days per week minimum at the Entrada Therapeutics Headquarters in Boston, MA. #LI-JF1 #LI-Hybrid 

The Perks

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

Privacy Statement

Entrada Therapeutics, Inc. (the “Entrada,” “we,” “us,” or “our”) respects your privacy and we want you to be familiar with how we collect, use, share, or otherwise process, your Personal Information. Please reference our privacy statement here to understand how and when your data is being used.

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